The experimental evidences acquired in this study imply that standardized ethanolic extract of Curcuma xanthorrhiza is non-toxic and suggest no potential health risk for human consumption. It can be concluded that this extract may has high level of safety margin, thus justifying its wide application in various communities coupled with lack of any reported serious side effects with the traditional use of this plant. However, further toxicity studies are required in order to justify the safety margin of this respective extract.