Fig. 1.
Selected analytical tools in rat genetics. A) The construction of recombinant inbred animals which are genetic mosaics of the two founding strains, consomic (chromosome substitution), congenic strains. B) An alternative method for fine-mapping small-effect QTLs uses outbred rats of known ancestry, genetically heterogeneous stock (HS). HS rats are generated by intercrossing several inbred progenitor strains followed by cross breeding for more than 50 generations.