There appears to be a complex relationship among stressful situations, our mind and body's reaction to stress, and the onset of clinical depression. It is clear that some people develop depression after a stressful event in their lives. Events such as the death of a loved one, the loss of a job, or the end of a relationship are often negative and traumatic and cause great stress for many people. Stress can also occur as the result of a more positive event such as getting married, moving to a new city, or starting a new job. It is not uncommon for either positive or negative events to become a crisis that precedes the development of clinical depression.