Revolutionary changes in the organization of work have far outpaced our knowledge about the implications of these changes for the quality of working life and for safety and health on the job. This gap in knowledge is one of the 21 priority areas for research under the National Occupational Research Agenda (NORA)—a framework crafted by the National Institute for Occupational Safety and Health (NIOSH) and its partners to guide research into the next decade. This report was developed under NORA as the first attempt to develop a compre- hensive research agenda for investigating and reducing occupational safety and health risks associated with the changing organization of work. Research and development needs identi- fied in the agenda include (1) improved surveillance mechanisms to better track how the organization of work is changing, (2) accelerated research on safety and health implications of the changing organization of work, (3) increased research focus on organizational interven- tions to protect safety and health, and (4) steps to formalize and nurture organization of work as a distinctive field in occupational safety and health.