exhibited an anti-gastric ulcer activity causing inhibition of gastric ulcer formation
induced by restraint water immersion, HCl/EtOH, indomethacin and histamine. In
pylorus ligated rats, the aqueous extract ofU. reticulatacaused a decrease of total
acidity and increase of gastric pH thus suggesting its possesses an anti-secretory
activity. In HCl/EtOH induced gastric ulcer, the aqueous extract of U. reticulata
could not protect the loss of gastric wall mucus or did not increase gastric mucus
secretion. Since the aqueous extract of U. reticulatahas an ability to form gel,
therefore it can be a protective barrier of the gastric mucosa against aggressive factors
or bind to ulcer tissues. Similarly tocimetidine, the aqueous extract of U. reticulata
could inhibit histamine induced increased heart rate of the isolated guinea-pig right