The disposed pressure-sensitive adhesive (PSA) tape widely used in daily life has been contaminating the environment and producing the vastly non-degradable trash. In this pioneering work, the advanced biodegradable pressure-sensitive double-coated tape containing starch carrier and water-soluble partially degradable modified pressure sensitive adhesive is architecturally designed and fabricated. The results have illustrated the excellent tack and peel adhesion of these newly constructed biodegradable self-adhesive tapes, and high thermal shear strength. Most importantly, the complete biodegradability of starch carrier and partially biodegradability of modified acrylic pressure-sensitive adhesives (PSA) have been confirmed experimentally. This environmentally friendly technology based on the starch resource utilization and novel water-soluble PSA will have great potentials for diverse applications such as the paper industry for manufacturing of ecological biodegradable product, the production of water-soluble biodegradable labels, medical tapes and biomedical electrodes.