Light microscopic findings of melasma include increased deposit of melanin in the epidermis and dermis or both when compared with adjacent normal skin and mild perivascular lymphohistiocytic infiltrates [5, 6]. Therefore the main aim of the treatment of melasma is to slow the proliferation of melanocytes and to inhibit formation of melanosomes as well as promotion of their degradation. These objectives can be achieved by inhibiting melanocytes activity, inhibiting melanin synthesis, removing melanin, and disrupting melanin granules contained within the melanosomes [7].