Body and Testicular WeightsBody weights did not differ significantly (P>0.05) among WT (31.5 ± 0.5 g), Hemi (34.3 ± 1.8 g), and Sickle (29.9 ± 1.0 g) mice. Testis weights (WT, 206.3 ± 4.2 mg; Hemi, 235.2 ± 4.3 mg; Sickle, 209.4 ± 7.3 mg) also did not differ (P>0.05).Decreased Serum and Intratesticular Testosterone Concentrations in Sickle MiceSerum testosterone levels were significantly lower in the Sickle mice as compared to WT and Hemi mice (P<0.05, Fig 1). Consistent with serum testosterone levels, intratesticular testosterone levels, whether expressed per gram testis or per testis, were significantly reduced in Sickle mice compared to WT mice (P<0.05) (Fig 2). Intratesticular testosterone levels were highly variable in the Hemi mice and so did not differ significantly (P>0.05) from the Sickle mice. However, there was a 2-3-fold difference in the means. These findings indicate that testosterone deficiency occurs in Sickle mice
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