Present case reports were recorded at College Hospital of College of Veterinary Science, Tirupati and Teaching Veterinary Clinical Complex, Proddatur during the five-years period from January 2009 to January 2014 of clinical study on dermatological cases. Dogs with dermatological problems were regularly screened for the ectoparasites and underlying factors for development of dermatological illness at major Veterinary Hospitals in four different districts of Andhra Pradesh. Superficial and deep skin scrapings, tape impression smears and hair plucks were collected from the affected dogs for laboratory examination. Scrapings were collected with scalpel blade dipped in liquid paraffin and collection of scrapings was continued until there was slight ooze of blood from dermal capillaries. Material was suspended in a few drops of liquid paraffin on a microscopic slide, a coverslip was applied and the preparation was examined under low and high magnifications (10X, 40X) of microscope. The acetate tape impression smears were used to investigate superficial mites [6]. Out of 1200 dogs examined with dermatological problems during the study two dogs were found to be affected with mixed demodectic and sarcoptic mange mites. From the two dogs blood was collected in 10% EDTA coated vials. Blood was processed for packed cell volume (PCV), haemoglobin (Hb), total leucocyte count (TLC), total erythrocyte count (TEC) and stained peripheral blood smears were for differential count (DLC) to know about the haematological abnormalities and to screen for any other infections.