The present study documents that both the incidence
of edema and patient withdrawal due to edema was
distinctly higher than reported in the PDR. Around
25% patients on CCBs were found to have peripheral
edema, and among those with edema, 25% was found to
withdraw from CCB due to edema. Edema rates were
dose dependent and found to increase with duration of
therapy for a period of up to 6 months. The rates were
higher with traditional DHPs compared with lipophilic
DHPs or non-DHPs.