Among the complex interplay of multitudinous pathophysiological factors of depression, oxidative stress has been reported to play a key role [13] and [14]. The theory of oxidative stress in depression, at its most basic, can be explained by the concept that excessive amount of free radicals are toxic to the neuronal cells and can affect the physiological activity of the brain [15] and [16]. The accumulated reactive oxygen species (ROS) are highly unstable in nature and have potential to damage cellular proteins, lipids and nucleic acids [15].