Fold And Fly
When you have to make it through the week living out of a carry-on, it's important to know a couple of tips and tricks. Heavy items, like your second pair of shoes (shoes should never be worn twice within 48 hours), go by the suitcase's wheels.
This keeps the bag maneuverable and will not put any wrinkles in your carefully folded shirts. Said shirts (of course, you bring one for each day and one extra) go into the plastic dry cleaning bags to keep wrinkles away.
If wrinkles happen regardless, hang them up in the shower the next morning and let the steam take care of the rest. Sandwich the dry cleaning bag full of shirts between your skirts or pants and blazers on top. Turn the blazer inside-out and places your rolled-up undergarments in the sleeves.
Put your toiletries in a plastic bag inside your laptop case, since those need to come out during security, anyway. Forget about bringing running gear along. It takes too much space in your bag, you will not have the time to go running anyway and chances are, it will make your fresh shirts smell of old trainers. Instead, bring a bathing suit and hop in the hotel pool.