Andrographolide exhibited high level of activity in murine
model when administered either with curcumin or
artesunate by the intraperitoneal route, without any toxicity.
The substantial decrease in level of parasitemia in response
to test drug combinations compared to the control and
extended periods of life, observed with the mice is the main
finding of the present study. This may be attributed to
the observed in vitro synergism or addictiveness between
the putative drug compounds in different combination
ratios. However, studies are in progress for effective dose
determination for complete clearance of parasitemia from
infected mice using AND+CUR and AND+AS combinations.