beneficial effects as direct aqueous radical scavengers;21,24,25 as myocardial salvage agents in experimental infarction models;26-29 and as cancer chemopreventive agents.30-33 The derivatives have shown increased utility as parenteral agents in these settings, as well as improved oral bioavailability in model animal studies.34 Acquisition of lycophyll through total synthesis (Schemes 1 and 2) should facilitate the generation of water-dispersible lycophyll salts. Such derivatives will likely find application in those indications in which parenteral delivery of highly potent radical scavengers possessing the lycopene scaffold is necessary to achieve their intended purpose. Specifically, these compounds will be evaluated for efficacy in contemporary in Vitro and in ViVo cancer chemoprevention models.