In summary, our results demonstrate that combinations
of P. emblica or T. bellerica extracts with doxorubicin or
cisplatin in A549 and HepG2 cell lines have a better effect
than either agent alone. Further studies are needed to
assess the underlying mechanism(s), signal transduction
pathways, leading to growth inhibition induced by single
agents and combinations both in vitro and in vivo. A positive
outcome of such studies would be increased efficacy
of existing chemotherapies with reduced toxicity to the
normal tissues in treatment of human lung carcinoma and
hepatocellular carcinoma.