Lignocaine should be used with caution in patients receiving other local
anaesthetics or agents structurally related to amide-type local anaesthetics, e.g.
antiarrhythmic drugs such as mexiletine, since the toxic effects are additive.
Specific interaction studies with lidocaine and anti-arrhythmic drugs class III (e.g.
amiodarone) have not been performed, but caution is advised.