This was paralleled in our murine model using
Trpv1, Trpv4, Trpa1 and pannexin-1 gene knockout (KO) mice.
Finally, we measured the expression of the TRP channels in
disease-relevant lung tissue harvested from patients with COPD
to provide convincing data implicating these ion channels in the
pathophysiology of COPD and highlighting them as novel
targets for therapeutic intervention.