Evaluation of the safety of color additives receives particular scrutiny, and the subject has been
summarized in several reviews (Marmion 1991, EFSA 2008, Food Advisory Committee 2011). The
possible allergenicity of food, drug, and cosmetic (FD&C) Yellow Number 5 (Tartrazine) caused
consumer concern in the 1980s, which had an impact on food labeling (Food Advisory Committee
2011) and stimulated some processors to convert to natural colorants. The possible link between
hyperactivity in children and the consumption of artificial food colorants has been revisited in the
Southampton study (McCann et al. 2007).