Guo et al., examined the effects of caffeinated coffee consumption on muscle weight, muscle strength, regenerative capacity, and the inflammatory milieu in elderly mice [10]. The mice who consumed caffeinated coffee in their drinking water over the 4-week treatment period showed greater muscle weight and grip strength compared to the control group, with no differences in body weight, food and liquid intake, nor physical activity. The control group lost muscle weight and strength while the treatment group did not. The prevention of the physical and functional decline was correlated with decreases in serum inflammatory mediators, such as IL-1α, IL-1β, IL-6, and TNF-α. Coffee consumption also accelerated the regeneration of muscle injured with cardiotoxin injection. Satellite cells isolated from aged mice and incubated with coffee for 72 h in culture exhibited greater rates of proliferation and DNA synthesis compared to control cells.