1. All-cause mortality.2. Cardiovascular mortality.3. Cardiovascular morbidity (including fatal and non-fatalmyocardial infarction, stroke, angina, h eart failure, peripheralvascular events, sudden death, revascularisation (coronary arterybypass surgery or angioplasty with or without stenting) andcardiovascular-related hospital admissions).We assessed pr imary outcomes at study e nd and also at the latesttrial f ollow-up, whe re participants had been foll owed observation-ally after the end of the original trial.