This research demonstrated the safety of using PPE,
supporting the traditional use of plaunotol in the form of
crude extracts. It was apparent that PPE treatment at the
therapeutic dose did not induce any lethal pathological or
clinical signs following chronic exposure. Therefore, it may
be possible to develop this extract as a human healthcare
product. Nevertheless, administration of high doses of PPE
over a long period of time may cause deterioration of the
liver and renal tissue, including increased blood platelet
levels. Therefore, hematological and biochemical values
should be monitored during use of high doses of the extract
over a long period of time.