Parasitological burdens and results are summarized in Table 1
(supplementary). There was a 59% reduction in worm burden in
the mice immunized with the recombinant protein in the presence
of CpG dinucleotides when compared to the adjuvant control
animals (p < 0.0001) (Fig. 2a). When compared to the saline group,
the experimental group had a 63% decrease in worm burden
(p < 0.0001). There were significant decreases in egg burdens as
well. Compared to the adjuvant control group, in the Sm-Cathepsin
B plus CpG dinucleotides group,there was a 56% decrease in hepaticegg burden (p = 0.0010), and a 54% decrease in intestinal egg burden
(p = 0.0008) (Fig. 2b and c respectively). Hepatic and intestinal egg
burdens were decreased by 63% and 64% respectively in the SmCathepsin
B plus CpG dinucleotides group compared to the saline
group (p < 0.0001). Overall, there were no significant changes in
parasitological burdens between the adjuvant and saline control
groups (Fig. 2).
Supplementary Table 1 related to this article can be found, in the
online version, a