Executiveattention(EA)isacore-constructofworkingmemory(WM)capacity.EAperformanceis
directlyrelatedtodorsolateralprefrontalcortex(DLPFC)activation,aneuralmechanismthatis
dysfunctionalinschizophrenia.Weexaminedthedifferencesinparticulartypesof EA failure in
schizophreniapatientsandhealthycontrols.Weevaluated executiveattention in 60medicated
schizophreniapatientsand60matchedhealthyindividuals.WeusedastandardWMtask,averbal
n-Back task,tomeasureexecutiveattention(WMaccuracy).Ourstandard-versionWMtask(control
block, 10minlong)wasdesignedtoexaminebaselineexecutiveattentionfunctionandwasfollowedby
one outofthreedifferentexperimentalblocks(revised n-Back tasks).Baselineexecutiveattention
performancewassignificantlyrelatedtopsychosisseverityandfunctionalcapacityinthepsychiatric
group. Inbothhealthyandpsychiatricgroups,experimental-blockconditionsrevealedthatdomain-
generalrecallhadadifferentialeffectonWMscores,andwasrelatedtothepatient’sclinicalcondition.
Only inthepsychiatricgroupdomain-specificrecallimpairmentsweremandatory,mostsevere,and
independentofbaselineWMscores.Theresultsrevealedtheimportanceofdomain-generalrecallWM
scoresintheevaluationofexecutiveattentiondeficitsinpatientsandcontrols.Disruptionindomain-
specificrecallmayrepresentaspecifierofcognitiveimpairmentinschizophreniaspectrumdisorders.
Executiveattention(EA)isacore-constructofworkingmemory(WM)capacity.EAperformanceis
directlyrelatedtodorsolateralprefrontalcortex(DLPFC)activation,aneuralmechanismthatis
dysfunctionalinschizophrenia.Weexaminedthedifferencesinparticulartypesof EA ความล้มเหลวใน
schizophreniapatientsandhealthycontrols.Weevaluated executiveattention ใน 60medicated
schizophreniapatientsand60matchedhealthyindividuals.WeusedastandardWMtask, averbal
งาน n-กลับ tomeasureexecutiveattention (WMaccuracy) .Ourstandard-versionWMtask
(ควบคุมบล็อก10minlong) wasdesignedtoexaminebaselineexecutiveattentionfunctionandwasfollowedby
หนึ่ง outofthreedifferentexperimentalblocks (ปรับปรุง n-กลับ tasks).Baselineexecutiveattention
performancewassignificantlyrelatedtopsychosisseverityandfunctionalcapacityinthepsychiatric
group. Inbothhealthyandpsychiatricgroups,experimental-blockconditionsrevealedthatdomain-
generalrecallhadadifferentialeffectonWMscores,andwasrelatedtothepatient'sclinicalcondition.
Only inthepsychiatricgroupdomain-specificrecallimpairmentsweremandatory,mostsevere,and
independentofbaselineWMscores.Theresultsrevealedtheimportanceofdomain-generalrecallWM
scoresintheevaluationofexecutiveattentiondeficitsinpatientsandcontrols.Disruptionindomain-
specificrecallmayrepresentaspecifierofcognitiveimpairmentinschizophreniaspectrumdisorders.
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