Smoking prevention efforts focus on attitude change, but scant information is available about the experiences that influence Chilean youth’s attitudes toward cigarettes. Results from the current study suggest that prevention efforts could benefit from gender specific strategies. Girls’ but not boys’ attitudes were influenced by peer pressure. Moreover, negative attitudes toward cigarettes were associated with lower current smoking in girls only. Parental smoking was an important influence on youth’s attitudes toward cigarettes. Efforts to reduce smoking among Chilean youth may benefit from concurrently reducing parental smoking.