This paper will review the status worldwide on technical and policy search for next-generation refrigerants with both
low Global Warming Potential (LGWP) and low Life Cycle Climate Performance (LCCP) with particular focus on
R410A replacement for unitary A/C & H/P. R32 and the HFO blends offer potential solutions but all involve tradeoffs
among Global Warming Potential (GWP), efficiency, safety, and cost. With the U.S. mandating new higher
regional efficiency standard taking effect January 2015, there is even more pressure in finding a Low-GWP
refrigerant solution that is affordable and can sustain efficiency and reduce charge requirement. This paper focuses
more on R32 as the available data for HFO blends is limited. Theoretical analyses and test results from various
drop-in system tests with different heat exchangers and scroll compressors will be presented comparing R32 and
HFO blends versus R410A. LCCP, system economics, compressor discharge temperature envelopes for typical US
applications, as well as A2L flammability safety aspects will be discussed relative to the HFOs.