O'Keeffe incorporated the techniques of other artists and was especially influenced by Paul Strand's use of cropping in his photographs; she was one of the first artists to adapt the method to painting by rendering close-ups of uniquely American objects that were highly detailed yet abstract.
O'Keeffe did not follow any specific artistic movement, but like Arthur Dove she experimented with abstracting motifs from nature. She worked in series, synthesizing abstraction and realism to produce works that emphasized the primary forms of nature. While some of these works are highly detailed, in others, she stripped away what she considered the inessential to focus on shape and color.
Through intense observation of nature, experimentation with scale, and nuanced use of line and color, O'Keeffe's art remained grounded in representation even while pushing at its limits. From the 1940s through the 1960s in particular, O'Keeffe's art was outside the mainstream as she was one of the few artists to adhere to representation in a period when others were exploring non-representation or had abandoned painting altogether.