The GMFM was developed for and has been validated for use with children with CP. The GMFM-66 has been validated only for use in children with CP tested in barefoot conditions.
The GMFM-88 has been used for children with spinal muscular atrophy, traumatic brain injury, and hereditary spastic paraplegia, There is an adapted version for children with Down syndrome and an abbreviated version for children with acute lymphoblastic leukemia. The abbreviated versions have only been validated for use with children with CP.