Centella has several pharmacological actions, based primarily on in vivo experiments. After oral and topical
administration in rats, increased cellular hyperplasia and collagen production were noted at the site of injury, measured
by increased granulation tissue levels of DNA, protein, total collagen, and hexosamine. More rapid maturation and
cross-linking of collagen were seen in animals treated with the herbal extract, as evidenced by elevated stability of acidsoluble
collagen and increases in aldehyde content and tensile strength. Compared to control wounds, rats treated with
gotu kola had a higher degree of epithelialization and a significantly more rapid rate of wound contraction.4,5