Additionally, they examined strategies for generating performance-enhanced versions of lysozyme, a natural antibacterial protein that helps protect humans from microbial invaders. To shield themselves from lysozyme mediated killing, some pathogens have evolved proteins that specifically bind and inactivate human lysozyme. Griswold demonstrated that it is possible to redesign the enzyme to evade these pathogen-derived inhibitory proteins, which resulted in modified lysozymes that can lyse bacteria under conditions where natural human lysozyme is completely inactivated.