Clostridium perfringens
Ananerobic gram + spore forming rod
Widely distributed in nature
Entry of spores by traumatic injury
Not highly invasive so it requires exoenzymes for a supportive growth environment
Exoenzymes
Lecithinase lipase c – major toxin
Lyses mammalian cells indiscriminately
Substrate is phophatidylcholine
Collagenase & hyaluronidase
DNAase