Coetzee et al. (2005) compared three different treatment regimens with OTC (30 mg/kg of a 300 mg/ml solution IM once; 30 mg/kg of a 300 mg/ml solution IM twice at a 5-day interval; and 22 mg/kg of a 200 mg/ml solution IV q24h for 5 days, which is the former OIE recommendation mentioned earlier) for persistent A. marginale infections