Diabetes mellitus is a serious chronic metabolic disorder characterized
by a decrease or cessation of insulin secretion in response
to normal physiological stimuli, or reduced responsiveness of peripheral tissues to insulin.1 The metabolic
abnormalities of diabetes cause mitochondrial superoxide
overproduction in endothelial cells of both large and small vessels,
as well as in the myocardium.
Therefore, oxidative stress
plays a major role in the development of diabetes complications,
both microvascular and cardiovascular complications