Beyond synthetic pollution, freshwater is also the end point for biological waste, in the form of human sewage, animal excrement, and rainwater runoff flavored by nutrient-rich fertilizers from yards and farms. These nutrients find their way through river systems into seas, sometimes creating coastal ocean zones void of oxygen—and therefore aquatic life—and making the connection between land and sea painfully obvious. When you dump paint down the drain, it often ends up in the ocean, via freshwater systems.