Transcriptional regulation of the laccase genes during different developmental stages was investigated by transcriptome analysis of the mycelium, primordium, and fruiting body (Fig. 2C). Among the twelve genes investigated, Lacc5 was highly expressed in the fruiting body, whereas Lacc1 and Lacc3 were expressed in the mycelium. Lacc12 was specifically expressed in the primordium. None of these genes have been extensively studied to date. Notably, Lacc6 was highly expressed at all stages. Lacc6 encodes a laccase protein similar to the blue laccase (GeneBank No. CAA06291) from P. ostreatus [31]. Lacc2 and Lacc7~Lacc11 were not significantly expressed under these conditions.