1. Infection Control:
Infection control is vital if the patient is to have any chance of survival. Appropriate broad-spectrum antibiotics must be given within the first hour of recognition of sepsis after obtaining various cultures. Evidence clearly shows that delay or inadequate antibiotic treatment results in poorer outcome. For every hour lost mortality climbs by 9%. [7]
Initial empirical anti-infective therapy should include one or more drugs that have activity against all likely pathogens (bacterial and/or fungal) and that penetrate in adequate concentrations into the presumed source of sepsis[8] antimicrobial regimen be reassessed daily to optimize activity, to prevent the development of resistance, to reduce toxicity, and to reduce costs
A focus of infection must be sought for and if discovered dealt with immediately. The patient should be evaluated for a focused infection amenable to source control measures including abscess drainage or tissue debridement. One must weigh up the benefits and risks of the particular procedure chosen. If intravascular devices are a potential source, they must be promptly removed after establishing other vascular access. When source control is required, the effective intervention associated with the least physiologic insult be employed (e.g., percutaneous rather than surgical drainage of an abscess)