In these healthy and young volunteers, ezetimibe consumption for
5 days did not significantly affect cholecalciferol absorption, when
compared with placebo. Absorption was estimated by serum 25OHD
14 days after a single oral 50,000 IU cholecalciferol dose taken with a
15 g fat meal. Results were adjusted for BMI and serum 25OHD levels
before cholecalciferol administration, which have been demonstrated
to predict the supplementation response [19].
Thestudy was conducted duringspringin thesouthernhemisphere,
when 25OHDlevelsarelikelytohavethelowestvaluesinthisarea