Different viruses have different strategies for penetration. Uncoating refers to the process in which the virions lose their outer coat and the viral genome is exposed. Some enveloped animal viruses are uncoated at the cytoplasmic membrane,releasing the virion contents into the cytoplasm. However,the entire virion of naked animal viruses and many enveloped animal viruses enters the cell via endocytosis. In such cases the virus must be uncoated inside the host cell so that the genome is exposed and replication can proceed.some enveloped viruses are uncoated in the cytoplasm. Others (such as influenza) are uncoated at the nuclear membrane and the viral genome then enters the nucleus. In animal cells,wherever uncoating occurs,the viral genome must eventually enter the nucleus to be replicated,except in a few rare cases.