Fenugreek:
Trigonella Foenum-graceum, commonly known as
Fenugreek, is an herbaceous plant of the leguminous family.
Fenugreek seeds contain a high percentage of mucilage (a
natural gummy substance present in the coatings of many
seeds). Although it does not dissolve in water, mucilage forms
a viscous tacky mass when exposed to fluids. Like other
mucilage- containing substances, fenugreek seeds swell up
82 and become slick when they are exposed to fluids .
The husk from the seeds is isolated by first reducing the size,
then separated by suspending the size reduced seeds in
chloroform for some time and then decanting. Successive
extraction with chloroform removes the oily portion which is
83 then air dried .
A different extraction procedure is also reported to isolate the
mucilage from the husk. The powdered seeds are extracted
with hexane then boiled in ethanol. The treated powder is then soaked in water and mechanically stirred and filtered. Filtrate
is then centrifuged, concentrated in vacuum and mixed with
96% ethanol. This is then stored in refrigerator for 4 hrs to
84 precipitate the mucilage .
The mucilage derived from the seeds of fenugreek, was
investigated for use in matrix formulations containing
propranolol hydrochloride. Methocel® K4M was used as a
standard controlled release polymer for comparison purposes.
A reduction in the release rate of propranolol hydrochloride
was observed with increase in concentration of the mucilage
in comparison to that observed with hypomellose matrices.
The rate of release of propranolol hydrochloride from
fenugreek mucilage matrices was mainly controlled by the
drug: mucilage ratio. Fenugreek mucilage at a concentration
of about 66% w/w was found to be a better release retardant
84 compared to hypomellose at equivalent content .
Fenugreek:
Trigonella Foenum-graceum, commonly known as
Fenugreek, is an herbaceous plant of the leguminous family.
Fenugreek seeds contain a high percentage of mucilage (a
natural gummy substance present in the coatings of many
seeds). Although it does not dissolve in water, mucilage forms
a viscous tacky mass when exposed to fluids. Like other
mucilage- containing substances, fenugreek seeds swell up
82 and become slick when they are exposed to fluids .
The husk from the seeds is isolated by first reducing the size,
then separated by suspending the size reduced seeds in
chloroform for some time and then decanting. Successive
extraction with chloroform removes the oily portion which is
83 then air dried .
A different extraction procedure is also reported to isolate the
mucilage from the husk. The powdered seeds are extracted
with hexane then boiled in ethanol. The treated powder is then soaked in water and mechanically stirred and filtered. Filtrate
is then centrifuged, concentrated in vacuum and mixed with
96% ethanol. This is then stored in refrigerator for 4 hrs to
84 precipitate the mucilage .
The mucilage derived from the seeds of fenugreek, was
investigated for use in matrix formulations containing
propranolol hydrochloride. Methocel® K4M was used as a
standard controlled release polymer for comparison purposes.
A reduction in the release rate of propranolol hydrochloride
was observed with increase in concentration of the mucilage
in comparison to that observed with hypomellose matrices.
The rate of release of propranolol hydrochloride from
fenugreek mucilage matrices was mainly controlled by the
drug: mucilage ratio. Fenugreek mucilage at a concentration
of about 66% w/w was found to be a better release retardant
84 compared to hypomellose at equivalent content .
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