Alprazolam and flunitrazepam also reduced liver ADH activity but to a smaller extent
(inhibition of 11.8 ± 5.0% for alprazolam 1.0 mM and 34.5 ± 7.1% for flunitrazepam 0.04 mM).
Apart from cimetidine, this is the first report describing the inhibitory effect of these drugs on ethanol metabolism.