No evident neuron loss is seen in rodents submitted to
flurothyl or PTZ recurrent seizures during development.
However, mossy fber sprouting occurs in adult animals.
Extratemporal areas can also be affected, including increased
prefrontal cortex thickness, synaptic plasticity alterations,
and decreased behavioral flexibility.These data indicate
substantial changes in prefrontal cortex function, which may
be an important substrate of cognitive defcits in humans with
a history of infant or juvenile seizures. Rodents submitted to
early-life flurothyl recurrent seizures present with increased
seizure susceptibility when they are adults. However, as
a limitation of this model, adult animals do not present with
spontaneous seizures.