Glucose sensors are of great interests from several points of
views ranging from medical applications of the blood glucose sensing
to ecological approaches. Since Clark and Lyons reported the
first enzyme electrode in 1962 [1], the efforts to develop and
improve glucose sensors, particularly based on amperometry, have
been made over four decades. Most studies on this subject have
involved the use of glucose oxidase, which catalyzes the oxidation
of glucose to gluconolactone. Although enzymatic detection
usually shows good selectivity and high sensitivity, the enzyme
is easily denatured during its immobilization processes. The most
serious problem of such sensor is the lack of stability due to
the intrinsic nature of enzymes [2,3]. In this aspect of view, the
development of nonenzymatic glucose detection still remains a
challenge.