These results indicate that RVTL has an important impact on neuronal plasticity, thus providing evidence of neuroprotective activity. According to the authors, “the survival of new born cells is of central importance, particularly because [their] general hypothesis is that adult hippocampal neurogenesis provides a «neurogenic reserve» that allows for the maintenance of cognitive flexibility in older age”. In spite of the relevance of this finding, the authors knew that cell survival itself might not be the only mechanism through which RVTL could act on the brain and so they explored other alternatives as well.