Considering the frequent occurrence of many of the environmental stressors discussed, simply attempting to avoid all of these stress-inducing situations is not an option. Stressors do not activate the HPA axis when the animal does not perceive the conditions as stressful [2]. Therefore, measures must be taken to reduce the negative impacts of and/or to acclimating cattle to these stressors to the greatest possible degree. Proper management practices, nutrition, and optimum climatic conditions are indispensable for homeostasis and optimum productivity in cattle. Innovative research aimed at determining causes and mechanisms of endocrine dysregulations induced by environmental stressors, is necessary. High impact research on nutritional regimens and on the proper means of controlling exposure of an animal to adverse climatic conditions is also required for efficient animal production systems, health, and enhanced product quality.