While no previous studies relating to the optimization of
extraction conditions for papaya leaves was found, studies on
other plant materials have reported similar findings. Nepote
et al. (2005) reported that extraction time had a significant
impact on extractability of phenolic compounds present in
peanut skins, while Alu’datt et al. (2011) found that with a
longer extraction time, both the overall yield of phenolic compounds
and the antioxidant activity of the extracts from olive
seeds improved.