The glucose tolerance in 18 of the 41 early-onset GDM patients normalized during
mid-gestation with appropriate nutrition therapy, defined as GDM ! NGT. These women
did not require insulin therapy during their pregnancies, whereas 39.1% of women who
retained GDM in mid-gestation (defined as GDM ! GDM) required insulin therapy. The
frequency of the postpartum development of type 2 diabetes or impaired glucose tolerance
was significantly lower (5.6% vs. 39.1% in GDM ! NGT vs. GDM ! GDM, p = 0.03). Primiparity
was determined as a predictive factor whether or not glucose intolerance was improved by
nutrition therapy, but results of plasma glucose levels from OGTT at early gestation were
not, in a multivariate logistic regression analysis.
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