For W8, the answer is no.
For W10, the answer will be yes but, not yet at this time. Officially, we don’t use W10 yet.
This what I know.
For TE Portal, there should be no problem as it runs under the Browser. Last release of IE11 is already OK for TE Portal.
Nevertheless, a test of TE Portal on W10 will soon be done.
Promise with SAPGUI under W10 has to be tested. According to SAP developers here, it should be OK.
For CAD applications, I suppose Eric Mahy can answer you.
I’m forwarding your question to Geert. He is in control of W10 project planning.