Because neoblasts are the only proliferative cells within
the body, irradiation that kills proliferating cells
selectively destroys neoblasts. Studies carried out
decades ago showed that in planarians, destroying the
neoblast population of adults by whole-body irradiation
results in gradual malformation of the body (as tissues
fail to be renewed) and eventually death [2]. Destruction
of the neoblast pool in planarians also abrogates the
typically extensive regenerative ability of these animals.
The study of De Mulder et al. demonstrates that in acoels
irradiation dramatically reduces cell proliferation,
abolishes the expression of a stem cell marker, and
ultimately leads to death [4], indicating that neoblasts are
required for homeostasis in acoels, as they are
platyhelminths. The selective destruction of neoblasts by
irradiation is a powerful tool in these animals. For
example, a key aspect of the microarray study described
above was the comparison of irradiated and unirradiated
planarian tissue to reveal neoblast-specific genes [7].
Because neoblasts are the only proliferative cells within the body, irradiation that kills proliferating cells selectively destroys neoblasts. Studies carried out decades ago showed that in planarians, destroying the neoblast population of adults by whole-body irradiation results in gradual malformation of the body (as tissues fail to be renewed) and eventually death [2]. Destruction of the neoblast pool in planarians also abrogates the typically extensive regenerative ability of these animals. The study of De Mulder et al. demonstrates that in acoels irradiation dramatically reduces cell proliferation, abolishes the expression of a stem cell marker, and ultimately leads to death [4], indicating that neoblasts are required for homeostasis in acoels, as they are platyhelminths. The selective destruction of neoblasts by irradiation is a powerful tool in these animals. For example, a key aspect of the microarray study described above was the comparison of irradiated and unirradiated planarian tissue to reveal neoblast-specific genes [7].
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