Minireview
The title of this minireview is inspired by the work of the Japanese artist Yayoi Kusama, who paints wonderful networks as one of her favorite subjects. As an artist, she can evoke images and concepts that are sometimes beyond her own knowledge: in this case her idea of a continuous network well suits a model of intercellular cytoskeletal linking suggested by a recent paper published in BMC Biology by Millan et al. [1]. Working with cultured human umbilical cord vein endothelial cells they find that actin-based stress fibers in adjacent endothelial cells in confluent culture can become linked through adherens junctions. This organization could, in theory, enable a communication network extending throughout the endothelium, as well as maintaining structural coherence and increasing resistance to stress. This capacity could be crucial to the function and adaptability of the endothelium, which is continuously exposed to changes in blood flow, whether in normal physiologic situations, or during inflammation or angiogenesis.
This is a novel extension of a concept first used for epithelial sheets [2] to endothelial monolayers.
MinireviewThe title of this minireview is inspired by the work of the Japanese artist Yayoi Kusama, who paints wonderful networks as one of her favorite subjects. As an artist, she can evoke images and concepts that are sometimes beyond her own knowledge: in this case her idea of a continuous network well suits a model of intercellular cytoskeletal linking suggested by a recent paper published in BMC Biology by Millan et al. [1]. Working with cultured human umbilical cord vein endothelial cells they find that actin-based stress fibers in adjacent endothelial cells in confluent culture can become linked through adherens junctions. This organization could, in theory, enable a communication network extending throughout the endothelium, as well as maintaining structural coherence and increasing resistance to stress. This capacity could be crucial to the function and adaptability of the endothelium, which is continuously exposed to changes in blood flow, whether in normal physiologic situations, or during inflammation or angiogenesis.This is a novel extension of a concept first used for epithelial sheets [2] to endothelial monolayers.
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Minireview
The title of this minireview is inspired by the work of the Japanese artist Yayoi Kusama, who paints wonderful networks as one of her favorite subjects. As an artist, she can evoke images and concepts that are sometimes beyond her own knowledge: in this case her idea of a continuous network well suits a model of intercellular cytoskeletal linking suggested by a recent paper published in BMC Biology by Millan et al. [1]. Working with cultured human umbilical cord vein endothelial cells they find that actin-based stress fibers in adjacent endothelial cells in confluent culture can become linked through adherens junctions. This organization could, in theory, enable a communication network extending throughout the endothelium, as well as maintaining structural coherence and increasing resistance to stress. This capacity could be crucial to the function and adaptability of the endothelium, which is continuously exposed to changes in blood flow, whether in normal physiologic situations, or during inflammation or angiogenesis.
This is a novel extension of a concept first used for epithelial sheets [2] to endothelial monolayers.
การแปล กรุณารอสักครู่..
