Thus, preventing pancreatic β-cell apoptosis and promoting insulin secretion of theβ-cell could be a
valuable therapeutic approach to cure diabetes.
Currently available therapies for diabetes include exercise,
insulin and various oral hypoglycaemic drugs, such as metformin,
sulphonylureas,α-glucosidase inhibitors, and rosiglitazone[7].Although multiple classes of oral drugs mentioned above have beneficial effects on repairing pancreatic islet cells damage and promoting
insulin secretion of pancreaticβ-cell in diabetes, most side effects
and drug resistance would occur after long-term use[8,9]. Therefore,
a critical need exists for the discovery of alternative agents that
would exert anti-hyperglycemic activity but exert fewer/no side
effects. Traditional Chinese medicine and herbal remedies, which
are multicomponent and have a long history of usage, act on significantly natural and safe sources of novel anti-hyperglycemic drugs
based on their excellent pharmacological activities[10,11].
Thus, preventing pancreatic β-cell apoptosis and promoting insulin secretion of theβ-cell could be avaluable therapeutic approach to cure diabetes.Currently available therapies for diabetes include exercise,insulin and various oral hypoglycaemic drugs, such as metformin,sulphonylureas,α-glucosidase inhibitors, and rosiglitazone[7].Although multiple classes of oral drugs mentioned above have beneficial effects on repairing pancreatic islet cells damage and promotinginsulin secretion of pancreaticβ-cell in diabetes, most side effectsand drug resistance would occur after long-term use[8,9]. Therefore,a critical need exists for the discovery of alternative agents thatwould exert anti-hyperglycemic activity but exert fewer/no sideeffects. Traditional Chinese medicine and herbal remedies, whichare multicomponent and have a long history of usage, act on significantly natural and safe sources of novel anti-hyperglycemic drugsbased on their excellent pharmacological activities[10,11].
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