A history of binge consumption of large
amounts of alcohol (C5 drinks per drinking episode or
[70 g alcohol per episode) [50, 51] conferred a 3.5-fold
increased risk of pancreatic cancer in men. Risk was
increased regardless of age when binge drinking first
occurred, although there was some evidence that risk was
greatest for binge drinking that began at 21–30 years of age
(p-trend = 0.007). A similar pattern was observed for
years since last binge drinking episode. Risk was increased
more than threefold regardless of when binge drinking last
occurred, although men whose last binge drinking episode
occurred 6–10 years before diagnosis/interview had a
greater than sixfold increased risk of pancreatic cancer.
Dose–response analyses provided additional support that
binge drinking increased risk of pancreatic cancer in men.
Risk was positively associated with increasing average
number of alcoholic drinks consumed during binge drinking
([15 drinks: OR = 4.4, p-trend = 0.002) and with
increasing years duration of binge drinking ([10 years:
OR = 3.7, p-trend = 0.0006)